Relationships between distributions of longevous population and trace elements in the agricultural ecosystem of Rugao County, Jiangsu, China. Cancer prevention in Europe: the Mediterranean diet as a protective choice. The deterioration of cells leads to several conditions associated with aging. ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity. Haus | Factors Influencing high adolescent pregnancy rate in Riobamba In Bangladesh, the challenges of public health highlight the importance of having a competent healthcare workforce . Spin biochemistry modulates reactive oxygen species (ROS) production by radio frequency magnetic fields. The number of older adults living alone in China is rising sharply. Available at: Lckenhoff C, De Fruyt F, Terracciano A, et al. The current study investigated HUA's prevalence and influencing factors in Gongcheng . By contrast, the health impact of multiple foods and nutrients in a complete diet merits serious consideration. (2006). In Bama, 70% of the telomere length in is heritable according to a clear maternal and paternal genetic model spanning > 2 generations [83]. Finger length ratio in longevity populations. However, humanistic education seems to be more beneficial from their unique ethnic culture that shapes their belief, thinking, and lifestyle [156, 157], with sustainable trans-generation preservation. 1C). 1) [1321]. All data generated or analysed during this study are included in this article and its supplementary material files. There was a larger proportion of female participants in the included studies, which might under-represent what males consider to be healthy ageing. Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Accessibility Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. If people can live more healthy years, it can improve quality of life for entire families. The hilly sandstone and limestone rocky mountain belts account for ~69% and ~30% of the total karst landform in the area [10]. Zhang L, Bai C, Nie C, Zhu X, Yuan H, Sun L, et al. Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors. Federal government websites often end in .gov or .mil. Conclusions According to the results, depression is the factor with the greatest influence on healthy aging. It highlights that being healthy is not solely determined by the absence of disease, even though may be a contributor. The characteristics of sunshine duration in Bama are partially consistent with the geographic distributions of the long-lived people there. Current scientific research on the Bama diet is not systematic. McDaid AF, Joshi PK, Porcu E, Komljenovic A, Li H, Sorrentino V, et al. (2010). 2014 Mar-Apr;58(2):205-13. doi: 10.1016/j.archger.2013.11.001. Moreno-Agostino D, Prina M, Chua KC, Jotheeswaran AT, Sadana R, Officer A, Kamenov K, Cieza A. BMJ Open. Many factors influence healthy aging. (2005). The determinant of outlook/attitude, found in seven studies, ties into self-awareness [1521]. Additionally, the inter-dependence between determinants supports the idea that healthy ageing is not a single stable measure, but that it is a balance that is constantly adjusted between all the determinants [28, 29]. Most centenarians maintained good states of lymphocyte proliferation, phagocytosis, and NK cells activity which extended their five-year lifespans [49, 50]. study due to the specific circumstance of MS being studied [17]. Study Design: The Gastrointestinal Microbiome and Allergic Proctocolitis (GMAP) study is a prospective observational cohort in suburban Massachusetts. Previous investigations sought longevity-related genomic variations. The water and soil of Bama abound in trace elements [130], the geomagnetic field has an appropriate "power window" [131], and the sunshine duration is appropriate [132]. Further enquiries can be directed to the corresponding author. Chen L, Ye M, Kahana E. A self-reliant umbrella: defining successful aging among the old-old (80+) in Shanghai. The Influence of the Earth's Magnetic Field on the Longevous Population of Bama County in Guangxi. government site. Increasing physical activity and eating a balanced diet has been shown to boost the mood and energy levels of individuals which consequently improves their attitude/outlook towards life [25, 26]. The ageing epigenome and its rejuvenation, Abnormal Epigenetic Regulation of Immune System during Aging. The ten determinants identified for healthy ageing include physical activity, diet, self-awareness, outlook/attitude, life-long learning, faith, social support, financial security, community engagement, and independence. Diet and Leukocyte Telomere Length in a Population with Extended Longevity: The Costa Rican Longevity and Healthy Aging Study (CRELES). The application of the results from this review to pre-existing longitudinal cohort data could provide direct comparison of these determinants in their contribution to healthy ageing at population level. The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications. These inter-relations could be because different people place a higher value on different determinants, depending on their subjective views or life experiences [27]. These studies emphasised the need to maintain a good level of physical capability to enhance successful healthy ageing. We need to care for ourselves and for each other as our population ages, so encouraging healthy lifestyle choices among the elderly is paramount. (2009). This finding was consistent with the observation in European longevity regions [31, 32]. Bama is a multi-ethnic region. Available at: Moher D, Liberati A, Tetzlaff J, Prisma Group et al. This is particularly important to evaluate whether all determinants have the same weighting towards defining healthy ageing and how it may vary with age, gender, race/ethnicity, and socioeconomic factors. Positive Lifestyle Factors That Promote Good Health The level of intrinsic capacity is influenced by several factors such as the presence of diseases, injuries and age-related changes. PFKFB4 is a key regulatory enzyme of glucose metabolism and the main energy source of various malignant tumor cells [59]. government site. Magnetic Resonance Imaging (MRI)). McDowell A, Thompson S, Stark M, Ou ZQ, Gould KS (2011). Careers, Unable to load your collection due to an error. Duran EK, Aday AW, Cook NR, Buring JE, Ridker PM, Pradhan AD (2020). These changes, in fact, are tenuously related to someones age in years. Int J Aging Hum Dev. The senescence-associated secretory phenotype: the dark side of tumor suppression. Additionally, by limiting the years of inclusion from 2010 to 2020, it was possible to focus on the most contemporary research available which builds on early established research in healthy ageing [28]. Qiu L, Yin RX, Khounphinith E, Zhang FH, Yang DZ, Pan SL (2018). TA and GK are joint first authors. Zou W, Gong L, Zhou F, Long Y, Li Z, Xiao Z, et al. Terry DF, Wilcox MA, McCormick MA, Pennington JY, Schoenhofen EA, Andersen SL, et al. Telomere length was negatively correlated with aging in the Bama population [83]. The Alzheimer's Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease: JACC Focus Seminar, Find drugs that delay many diseases of old age, How the ageing microenvironment influences tumour progression. Some literatures have suggested that change in leukocyte telomere length may be a more relevant metric than static levels [94, 95]. Bitter vegetables such as Sonchus oleraceus L. are widely distributed in Bama. By creating a clear framework of the factors that influence healthy ageing at an individual level, public service providers and policy makers can be guided to identify and give incentives to work towards improvement in health focusing on specific determinants that are relevant to an individuals circumstances. The concept of healthy ageing is likely to be a dynamic process meaning important determinants may even vary within an individual depending on their age, further evaluation of relative contribution these determinants is warranted, albeit this is beyond the scope of the current study. Li Y, Huang Y, Liang X, Long B, Chen S, Lian J, et al. No restriction was placed on geographical location. focused on incarcerated women as participants and created a framework that had the five stages of successful ageing [15]. Long-lived people may have a unique "longevity element spectrum" characterized by a healthy balance between the synergistic and antagonistic efficacy of trace elements. Correlation between Changes in Local Earth's Magnetic Field and Cases of Acute Myocardial Infarction. The latter is the basis of precision medicine [168]. What factors influence healthy aging? A personcentered approach among Three studies used diet as a determinant for physical health, yet the specifics of the kind of diet or nutritional elements were not reported [14, 15, 17]. (2016). The .gov means its official. These natural compounds exhibit antioxidant [113-115], anticancer [115-119], antitumor [118, 120], antibacterial [118, 121], anti-inflammatory [122-128], or anti-infection [122] efficacy that may be involved in longevity (Fig. Cheng F, Carroll L, Joglekar MV, Januszewski AS, Wong KK, Hardikar AA, et al. (2021). Careers, Unable to load your collection due to an error. (2014). The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer. Fu J, Zhang Y, Hu Y, Zhao G, Tang Y, Zou L (2020). There are approximately 34 people over 90 years of age per 10,000 in the hilly sandstone belt and at least two of them are centenarians. For example, in the physical domain both determinants, physical activity and diet can affect the mental/cognitive determinant of attitude/outlook. (3) There are gender differences in the distribution of the long-lived population in Bama. (2015). A Lesson from the Longevity Village of Bama in China DOI: 10.14336/AD.2022.1108 Authors: Wei Zhang Qingyun Huang Yongxin Kang Hao Li Show all 5. Future research would be to conduct a sense-checking exercise via focus group work with older adults to propose the new framework and whether this framework fits with their concept of healthy ageing. specifies that engaging in active learning is very important in successful healthy ageing particularly in the field of technology [14]. Ageing and health - World Health Organization (WHO) About 40-60% of the variation in serum lipid profiles is genetically determined [33, 34]. Barbagallo M, Veronese N, Dominguez LJ (2021). Current research on telomeres and aging indicates that telomere dysfunction attenuates mitochondrial biogenesis and function, downregulates genes encoding antioxidant defense, and accelerates aging [89]. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Sonchus oleraceus L. contains abundant antioxidants, -3 FA, phenols, and flavonoids [104]. the contents by NLM or the National Institutes of Health. Deng Q, Chen L, Wei Y, Li Y, Han X, Liang W, et al. those with MS differed from those without. Reasons for exclusion at full-text screening stage are reported in the PRISMA flow chart (Fig. The numbers within each shape overlap represents how many studies included that combination of determinants. in China, Anti-ageing effects of Sonchus oleraceus L. (puha) leaf extracts on H(2)O(2)-induced cell senescence. Observational research rigour alone does not justify causal inference. Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. eCollection 2022. Thus, appropriate sunlight duration may be conducive to human health. This diet promotes health and longevity, which has also been verified in mice [101]. (2020). An official website of the United States government. Data were independently extracted from included studies by two reviewers (TA, GK). (2) They are mostly from ethnic minorities. (2021). Approach F-1: Identify and understand environmental, social, cultural, behavioral, and biological factors that create and sustain health disparities among older adults. and transmitted securely. Results: Though trace elements comprise only a minuscule portion of the human body, they nonetheless have a significant impact on it. (2016). Figure2 shows the combination of determinants found in each study by the overlapping of the shapes, each of which represents a study. Bama has typical karst landforms, and limestone rocky mountain and hilly sandstone belts comprise most of the landscape. Cytotoxic T lymphocytes and NK cells were also detected in the Japanese centenarians with superior resistance to various diseases [48]. Prevalence and influencing factors of hyperuricemia in middle - Nature In considering what factors impact healthy aging, we suggest that a person-centered approach would be useful and critical for policy makers to understand the compositions of health profiles and the influencing factors in view of a life-course perspective. For this systematic review, outcomes also included identification of determinants that fall within the three domains of physical, mental/cognitive, and social well-being. Aging Types, Causes, and Prevention - Verywell Health who focused on Chinese immigrants living in Australia [20]. Maciag D, Dobrowolska E, Sharafan M, Ekiert H, Tomczyk M, Szopa A (2021). Yuan J, Chang SY, Yin SG, Liu ZY, Cheng X, Liu XJ, et al. Beekman M, Blanche H, Perola M, Hervonen A, Bezrukov V, Sikora E, et al. Telomere shortening can trigger a number of secondary pro-aging phenomena such as increased DNA damage and genomic instability, cellular senescence and/or apoptosis, etc. Two focused on Multiple Sclerosis (MS) patients [17, 19], one on incarcerated women [15], and one on immigrants [20]. Physical exercise shapes the mouse brain epigenome. Liu YL, Luo KL, Lin XX, Gao X, Ni RX, Wang SB, et al. Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Biologists empirically confirmed that lifespan and aging have genetic traits [18, 19]. Genetic factors. definition of body awareness, specifically relating to ones lifestyle choices [17]. Older people can also make important contributions to their families and communities, bringing important insights from living through change. (2013). Animal models could also be used in the future to segregate the influences of dietary factors from those of lifestyle and cultural customs on longevity and aging in Bama. Several factors are responsible for ageing: age, sleep, dietary habits, nutrition, physical activity, general health condition, emotional well-being, physical impairment, cultural factors, life events, social support, family well-being, financial resources, cognitive functioning, and diseases. Determinants of healthy ageing: a systematic review of contemporary Aging is a period in the life cycle experienced by everyone [].The world population is aging rapidly, and the global proportion of people aged 60 and over will reach from 11% in 2006 to 22% in 2050 [2, 3].In 2050, the world's elderly population is estimated to be multiplied by children under the age of 5, and in the next 50 years, the elderly population will reach two billion . Of the nine studies, there were five that had determinants that covered more than a single domain, meaning the determinant could not be solely classified into one domain [14, 15, 17, 18, 20]. Every person in every country in the world should have the opportunity to live a long and healthy life. Using some candidate longevity genes screened from Bama longevity population to explore these genes and the molecular mechanisms of aging can provide novel insights into aging interventions. The ten determinants identified for healthy ageing include physical activity, diet, self-awareness, outlook/attitude, life-long learning, faith, social support, financial security, community engagement, and independence. 1. Silva-Sena GG, Camporez D, Santos LRD, Silva ASD, Sagrillo Pimassoni LH, Tieppo A, et al. Being informed and intentional about diet, activity, sleep, or smoking can reduce your health risks and potentially add years to your life. (1) The regional distribution of the long-lived elderly in Bama shows spatial aggregation by using GIS to sort out the data. Progress in the study of physical anthropology of minorities and molecular genetics of osteoporosis, Journal of Youjiang Medical University for Nationalities. Which Factors Influence Healthy Aging? A Lesson from the - PubMed Importantly, the Zhuang, Yao, and Han accounted for 56%, 25%, and 19% of the centenarians, respectively (Fig. Linking what we eat to our mood: a review of diet, dietary antioxidants, and depression. Mental Health Status and Coping Behaviors of the Guangxi Baiku Yao Population in Response to Life Events. Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice. Hence, conducting in-depth investigations on telomeres and human longevity using the longevity resources of Bama combined with various methods to measure telomere length [96, 97] may provide strategies for the treatment of aging and aging-related diseases and the prognostication of advanced cancers. In reality, there is enormous diversity in old age. A meta-analysis of Caucasians, Chinese, and Koreans disclosed that ACE D alleles and DD genotypes moderately but significantly increase longevity [40]. (2008). Clipboard, Search History, and several other advanced features are temporarily unavailable. These learnings may facilitate the development and implementation of measures preventing unhealthy aging, establish a suitable living environment, and promote a healthful lifestyle. The determinants of healthy ageing can vary depending on many factors, including culture, age, and gender. This includes their homes, communities, and socioeconomic status. Besides, in studies on longevity, observational research often emerges [162-164], but has disadvantages of subjective judgement [165]. The longevity studies in Bama indicate that formulating differentiated population aging strategies may guide the establishment and maintenance of a healthy aging society. Main specific genetic factors are related to longevity in Bama, China. Despite these advancements, there remains a knowledge gap in understanding the association between active aging determinants and quality of life (QoL) among older adults, particularly . This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. Additionally, continuous learning has a good cognitive impact aiding in maintaining ones cognitive function as they age. surveys) [13, 17, 18]. On the contrary, red and processed meat consumption has been linked to increased mortality, CVD, and some types of cancer. In contrast, the rates of SIRT6 methylation were significantly decreased at the P2 and P5 CpG in the Bama longevity population. Jarusevicius G, Rugelis T, McCraty R, Landauskas M, Berskiene K, Vainoras A (2018). Frontiers | Factors influencing age of common allergen introduction in Springer Nature - PMC COVID-19 Collection, http://bioinformatics.psb.ugent.be/cgi-bin/liste/Venn/calculate_venn.htpl, https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Highlights.pdf, https://www.who.int/about/who-we-are/constitution, https://casp-uk.net/wp-content/uploads/2018/01/CASP-Qualitative-Checklist-2018.pdf, https://www.who.int/initiatives/decade-of-healthy-ageing, Conceptual Framework of Healthy Ageing with Multiple Sclerosis, Qualitative (Focus groups and interviews), The Road to Success Model: 5 Phases of Successful Ageing of Incarcerated Women, Umbrella Model for Self-Reliant Successful Ageing. Most of the studies were qualitative in nature and employed either semi-structured interviews or focus groups. National Library of Medicine Environmental factors have an enormous impact on human life expectancy and even alter genetic traits [129]. 1Department of Human Anatomy, Institute of Neuroscience and Guangxi Key Laboratory of Brain Science, Guangxi Health Commission Key Laboratory of Basic Research on Brain Function and Disease, School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China. Liu Y, Li Y, Jiang Y, Li H, Wang W, Yang L (2013). Targeting muscle-enriched long non-coding RNA H19 reverses pathological cardiac hypertrophy. H19 methylation and inhibition may help people avoid lethal age-related diseases, thereby increasing the possibility of living longer [47, 57, 58]. Lew WZ, Feng SW, Lee SY, Huang HM (2021). The aforementioned studies consistently demonstrated that the elderly had a unique DNA methylation pattern that delays the onset of aging-related diseases and favors longevity by repressing the genes associated with susceptibility to them. Where someone lives can also affect how they age. Description of Lifestyle, Including Social Life, Diet and Physical Activity, of People >/=90 years Living in Ikaria, a Longevity Blue Zone. Hence, they had elevated SIRT6 mRNA levels. Healthy ageing and functional ability - World Health Organization (WHO) SIRT6, a member of the SIRT family, usually functions as a protein deacylase [63]. In fact, combining sociological and scientific methods have been used to reduce the error of age statistics in many longevity studies of Bama, including evaluating the bone age, checking registered residence, genealogy, and investigating social relations [23, 155]. Healthy ageing is about creating the environments and opportunities that enable people to be and do what they value throughout their lives. Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, et al. Some 80-year-olds have levels of physical and mental capacity that compare favourably with 30-year-olds. Influence of Sociodemographic, Behavioral and Other Health-Related Lastly, faith was found in five studies, which included the aspects of beliefs, religion, and spirituality [14, 15, 17, 18, 21]. Thus, Mg helps prevent certain aging-related conditions such as Alzheimer's disease, insulin resistance, T2DM, hypertension, and CVD [139]. The multifactorial process of ageing is one of the biggest biological and medical challenges of the 21st century with age-related conditions such as cardiovascular diseases, neurodegeneration and cancer being among the leading causes of death among industrialized countries. Hear loss and impaired vision, such as cataracts, are common amongst older people. (2019). Available at: Modesti P, Reboldi G, Cappuccio F, et al. defined financial security as being able to maintain a good quality of life [18], whereas Hui Chian Teh et al. Social isolation and loneliness are important, yet neglected, social determinants of the health of older people. Data analysis shows that Yao minority appears to have highest normalized longevity index of the centenarians among the different ethnic groups, implying a positive link between the genetic background of Yao and longevity in Bama. Most studies had a sample size greater than 100, and were predominantly conducted in Asia [1316]. Personalized treatment based on unique gene mutation research and multi-target drug development based on medicinal herbs provide new directions for the advancement of gerontology [169]. The .gov means its official. Yet, the environments in which we live can favour health or be harmful to it. Building blocks of successful aging: a focus group study of older adults perceived contributors to successful aging. All studies were found to be of high quality according to the CASP Checklist for qualitative studies and the NOS for cross-sectional studies (Supplementary Table 2, Supplementary Table 3). As a library, NLM provides access to scientific literature. (2009). 1. Social environments can also affect lifestyle choices among the elderly. We examined the impact of genetic and environmental factors on longevity from multiple perspectives. The Zhuang and Yao minority accounted for 69% and 16% of the elderly over 90 years of age, respectively, while Chinese Han accounted 15%. Petkovich DA, Podolskiy DI, Lobanov AV, Lee SG, Miller RA, Gladyshev VN (2017). Understanding and managing stomach cancer risk factors, Significance of a healthy mind for a healthy body. Phytochemicals, pharmacology, clinical application, patents, and products of Amomi fructus. J Gerontol B Psychol Sci Soc Sci. The woodland has dense plant populations, the residential areas are scattered, and there is only sparse cultivated land. Mn regulates glucose and lipid metabolism, accelerates protein and vitamin synthesis, controls the endocrine system, and maintains normal immune function [141]. The authors would like to thank Dr Stavroula Lila Kastora for constructive criticism of the manuscript. In their own words: a model of healthy aging. People may also experience cognitive deterioration, including dementia or Alzheimers. Here, these above studies conducted on the long-lived population in Bama, China, have given us some important lessons: (1) Several SNPs elevate HDL-C and lower LDL-C and TG levels, which may reduce the risk of cardiovascular diseases; (2) DNA methylation may repress the expression of susceptibility genes and increase that of longevity genes; (3) Telomere length is heritable and may affect antioxidant efficacy, tolerance and inflammation, respectively; (4) The diet pattern consisting of hemp seeds and Sonchus oleraceus L. etc. Association between lncRNA H19 polymorphisms and cancer susceptibility based on a meta-analysis from 25 studies. Zanthoxylum nitidum (Roxb.) Arch Gerontol Geriatr. The incidences of age-related cerebro-vascular diseases, type 2 diabetes mellitus (T2DM), cancer, and neurodegenerative diseases are rapidly rising as the elderly population sharply rises [1-5]. Method: We sourced participants, older than 55 years with MS for more than 20 years, from a database of MS clinic and outpatient rehabilitation visits. We carried out a systematic review by searching five electronic databases (EMBASE, MEDLINE, Cochrane, PsychINFO, and CINAHL) from January 2010 to November 2020 to capture contemporary evidence. Liu C, Chen L, You Z, Wu Y, Wang C, Zhang G, et al. Rather than one single causative factor, a range of environmental, demographic, biological, behavioral and social factors . About 12 of these individuals are centenarians. Nong QQ, Chen XD, He M, Qin J, Zhang ZY, Li CH, et al. (2003). (2014). Sirtuins as regulators of metabolism and healthspan, Telomeres and sirtuins: at the end we meet again. Since ancient times, people here believe that benevolent people live longer and thus have little mental stress with a simple lifestyle. Over time, our cells ability to repair damage and maintain their integrity deteriorates. Recent studies suggested that DNA methylation is related to age-related sites and longevity [44-46]. Eligible studies needed to report a clear framework of healthy ageing in humans, within one or more of three domains (physical, mental/cognitive, social), in English. The correlation between longevity and environment is a hot research topic in modern gerontology, as this association may reflect the proclivity of healthy aging. Diet is particularly important for healthy aging. Jin Z, Chen S, Jin J, Chen K, Sun Y, Zhao M (2021). Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. Shui S, Wang X, Chiang JY, Zheng L (2015). Available at: Jowell A, Carstensen L, Barry M. A life-course model for healthier ageing: lessons learned during the COVID-19 pandemic. The provision of safe and accessible public places are examples of things policymakers can do to help older people live better lives. (2017). Based on the factors identified as influencing healthy aging at the individual level, it is imperative from a policy-making perspective to maximize opportunities for healthy aging. Bonafe M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, et al. Qin YR, Zhang ZY, Gan YF, Qin J, Lu HX, Su J, et al. Hence, Bama is an ideal subject for research into healthy aging. Factors influencing healthy aging include a balanced diet, regular physical activity, and reduced alcohol and tobacco consumption. Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span.